August 12, 2003 Thesis Chemistry
Thesis Chemistry and Daicel
Chemical Industries announce a collaborative business development
agreement for chiral
process manufacturing
Thesis
Chemistry, LLC (Thesis),
and Daicel
Chemical Industries, Ltd. (Daicel),
announce a Collaborative Business Development Agreement wherein
Daicel's CPI Company will provide custom manufacturing and
biotransformation services related to Thesis' third-party
projects.
"Our agreement with Daicel fulfills Thesis' commitment to
provide our customers with integrated chemical development
services supporting pre-clinical to commercial supply of
pharmaceutical chemicals," says Dr. John R. Peterson, Chief
Executive Officer and President of Thesis Chemistry. "We
carefully selected our manufacturing partner so as to complement
the offerings of our existing industry partners and to be able to
match our customer's project requirements with the broadest
spectrum of commercial-scale processing technologies for
production of single-handed (chiral) fine chemicals and
pharmaceuticals. Daicel's technologies in organic synthesis,
enzymatic biotransformations and chromatographic separations are
geared towards the manufacture of chiral pharmaceutical chemicals
in quantities up to multi-metric tons."
"Daicel is pleased to partner with Thesis Chemistry and
provide its customers with custom manufacturing and development
services related to our core technologies for producing chiral
pharmaceutical chemicals", says Dr. Takeshi Matsumoto,
General Manager, Daicel Chemical Industries, CPI Company.
"In particular, we normally rely on SMB chromatography and
biotransformations to obtain the best economic and technical
solution for a customer's chiral process."
Thesis Chemistry, LLC manages and provides chemical development
services to the pharmaceutical, animal health and generic drug
industries. The Company links its process development
capabilities and familiarity with the regulatory requirements of
drug manufacture with the resources of its industry partners for
contract supply of developmental quantities of pre-clinical and
clinical drugs, custom manufacture of bulk substance and sourcing
of raw materials and process intermediates used in the
manufacture of drugs. Thesis has established agreements with Chiral
Technologies, Inc. (a
subsidiary of Daicel) for chiral separations, Regis
Technologies, Inc. for
production of preclinical and clinical drugs and intermediates,
and with Major Chemicals Co., Ltd. and S. Amit & Co. for economical sourcing of raw materials
and early processing intermediates from China and India,
respectively.
Daicel Chemical Industries, Ltd., with headquarters in Japan, is
a global chemical manufacturer with consolidated sales over $2
billion. Daicel was established in 1919 through a merger of eight
celluloid companies, under the name Dainippon Celluloid Co., Ltd.
The company's growth includes various cellulosic derivatives,
organic chemicals, plastics, film, airbags, and chiral
chromatography. The CPI Company division offers a wide range of
organic syntheses combined with biotechnologies and integrated
chiral technologies for the pharmaceutical and agrochemical
industries. Today, Daicel supplies chiral synthons and custom
manufactures intermediates and bulk actives under cGMP and ISO
standards from investigational to commercial scale. SMB, a form
of industrial scale chromatographic separation, and bioreactions
(biotransformation) using a variety of microbes including
recombinant bacteria are core technologies that Daicel uses to
introduce chirality into a fine chemical.
Daicel's CPI Company http://www.daicel.co.jp/cpi/jp/index.html
医薬中間体・原体の開発から工業生産までをサポート
− キラル化合物のエキスパート −
ダイセル化学は、キラル化合物の開発に関わる技術と経験を生かし、お客様の医薬品開発の全てのステージにおいて、医薬中間体・原体の研究開発から工業生産までをサポートします。
ダイセル化学のキラル事業の歴史
ダイセル化学工業は長年にわたる有機合成化学・セルロース化学・高分子合成化学の各分野で蓄積してきた技術を結集して、画期的な光学異性体分離用カラムを開発いたしました。ダイセル化学のキラル事業の歴史は、1979年のアクリル系ポリマーの不斉合成法開発に始まります。以来、光学異性体分析用カラムの製造販売、分取用カラムの製造販売、受託分離事業参入など、市場のニーズにいち早く応えてきました。
1979年：
アクリル系ポリマーの不斉重合法開発
1980年：
アクリル系ポリマーの光学異性体分割能の発見
1982年：
光学活性体ポリマーを利用した世界最初のカラム上市「CHIRALPAK
OT」
光学異性体分析用カラム販売開始
1986年： 受託分離ビジネス開始
1990年： 大型分取設備新設､受託分離拡大
1991年： 米国拠点設立 「Chiral
Technologies,Inc」
1993年： キラルテクノロジー社(米国)にて受託分離ビジネス開始
1996年： 欧州拠点設立「Chiral Technologies-Europe
SARL」
Chiral
Technologies 新立地取得
Chiral Technologies http://www.chiraltech.com/
Chiral Technologies provides
technical support, services and products to assist customers
in Europe and North America in the analysis and separation of
racemic compounds. For assistance in Asia, customers may
contact Daicel Chemical Industries, Ltd. (Tokyo, Japan), a
multi-billion dollar company with established expertise in
cellulose chemistry and separation technologies. Daicel Chemical
Industries, Ltd. is the parent company of Chiral
Technologies.
Chiral Technologies focuses its resources on chromatographic
resolution - the fastest, most effective means of analyzing
chiral compounds and obtaining pure enantiomers. A staff of
experienced scientists and engineers at each Technical Center
develops methods, provides customer support services and
develops new application data. Our products and custom
separation services are accomplished in facilities that
comply with cGMP quality guidelines.
Daicel chiral HPLC columns, the most widely used and
referenced chiral chromatography products in the world, are
available from Chiral Technologies in Europe and North
America. The core technology for Daicel chromatography
products is polysaccharide-type chiral stationary phases.
This technology has its origins with the research and
resulting inventions of Professor Y. Okamoto of Nagoya
University, Japan. Continued product development has resulted
in bulk chiral stationary phase, preparative and process
scale columns, simulated moving bed (SMB) chromatography
technology and the availability of custom separation
services.
Thesis Chemistry, LLC http://www.thesischemistry.com/
Thesis Chemistry provides the
chemistry necessary to take your drug from concept to
commercialization.
Serving the pharmaceutical, animal health and allied industries,
Thesis Chemistry offers the highest-quality contract chemistry
services, while operating
under FDA guidelines, in support of your drug development and
manufacturing needs.
Established in 2002, Thesis Chemistry delivers quality, speed,
cost effectiveness and a customer-focused philosophy that makes
us your ideal development partner. Thesis Chemistry, LLC is
headquarted in Cleveland, Ohio and operates a subsidiary, Thesis
Chemistry Inc. in Ontario, Canada.
Thesis Chemistry brings the chemical resources of a network of
premier chemical industry partners to task on a project. This
novel approach at chemical development matches ours and the best
of the industry's technologies and capabilities to your specific
project requirements. You benefit by a reduced outsourcing
burden, access to the best technologies, lower cost and shortened
time of manufacture.
Regis Technologies, Inc. http://www.registech.com/
For over 40 years, Regis
Technologies, Inc. has served as a partner in the development,
scale-up, and manufacture of complex, multi-step custom synthetic
products for clients in the pharmaceutical, diagnostic, and
biotech industries. Our extensive organic expertise and our
collegiate collaborations have resulted in a number of innovative
chromatography products, especially those with a chiral emphasis.
Major Chemicals Co., Ltd http://www.chemnet.com/
Major Chemicals Co., ltd.has over
10 years experience in international business mainly dealing with
various pharmaceutical raw materials , intermediates, herb
extracts , food additives
and hormones etc. .
We have a good reputation in USA , EU and South American Markets.
S. Amit & Co. (Mumbai, India) http://www.s-amit.com/
The S.Amit Group has been in the
business of selling and marketing chemistry for over four
decades, has recognition in chemical Industry.
Our marketing has always been information based. We have
endeavoured to be unique and get service oriented in all the
activities that we undertake.
Our emphasis has always been on the needs of our Customers and
Business Partners and this has been our focal point of business.
It has been our commitment to provide our organisation a
structure to keep pace with the growing and ever changing needs
of the business today as recognised by our Customers and Business
Partners. With our constant endeavour to optimise customer's
progress, we have today created a sound organisation with
information technology enabled infrastructure for Overseas
Representation and Distribution, so as to provide a total package
of facilities for the Customers and Principals alike
Today we represent number of overseas and few national Principals
for their Chemicals & Intermediates and performance chemicals
for application in Pharmaceuticals, Agrochemicals, Paints,
Polymer, Rubber, Ink, Personal Care, Food, Paper Industry. We
always believed to be a intermediary with a difference and our
strength have always been in analysis and quality of information
and knowledge on the various products and Industries and this
makes us different as an Infomediary and not a mere point of
contact.
We believe in marketing the products of our Principals to the
Industry by their chemistry and thus add value to the Customers
and Principals alike, resulting in a win-win situation. We
practice a sound code of business ethics and have a
well-structured organisation with emphasis on technical and
marketing competence and this makes us beyond a mere point of
contact.
Our other area of strength is the Customs Synthesis, or shall we
say Custom Solution wherein we bring the Producer and Buyer
closer to each other depending on their strengths of chemistry,
understand the synergy and thus convert under-utilised
capabilities and capacities to opportunities.